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Source: Hwang, et al JAMA Health Forum March 14, 2025 Researchers from the University of Chicago modeled the clinical and financial impact of anti-obesity medications: Zepbound (tirzepatide), Wegovy (semaglutide), and two oral generic drug combinations, phentermine-topiramate and naltrexone-bupropion

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This can be especially helpful when appetite returns after GLP-1 changes

IS and OS therapy were well tolerated, and no patients in both groups experienced severe adverse events like nausea or vomiting