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The morphology of morroniside-treated HFs was characteristic of anagen phase, with thicker skin and larger hair bulges surrounded by increased melanin and more bulbs in the subcutis (Fig

Moreover, phosphorylation events similar to those observed in other E3 ligases could potentially regulate the transition between inactive and active states 54,55,56

One distinctive feature is a clear zone of normal skin directly bordering the lips, with the rash beginning just beyond that margin