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Dean OM, Gray KM, Villagonzalo KA, Dodd S, Mohebbi M, Vick T, et al

91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways