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Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]
Combining the two might theoretically exacerbate digestive symptoms in susceptible individuals, though this has not been systematically studied
In speaking with a friend who shared her own weight loss struggles, our conversation surrounded semaglutide injections as a way to kickstart a diet while learning how to make lifestyle changes
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