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The efficacy and safety profile of the DPP-4 inhibitors shows a favorable profile of the DPP-4 inhibitors especially for patients with renal impairment as well as elderly subjects with type-2-diabetes
The action of GLP-1 RAs is to enhance insulin synthesis and inhibit glucagon secretion by activating GLP-1 receptors
Superoxide dismutases convert superoxide enzymatically into hydrogen peroxide, which can be converted into water either by glutathione peroxidase or catalase
Subsequent oxidative stress damages cellular DNA and organelles, activating repair processes that inadvertently divert glucose metabolism toward harmful pathways [24]
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