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Combination with insulin may be necessary in patients with advanced beta cell dysfunction, though the dual agonism effects may reduce insulin requirements compared to traditional approaches

Nevertheless, it is noteworthy that in the recently reported SOUL trial of 9,650 individuals 70 with T2D and established atherosclerotic cardiovascular disease or chronic kidney disease semaglutide 14 mg daily was associated with a reduction in adjudicated major adverse limb events, a finding that was also observed numerically in the FLOW trial

While primarily used for diabetes, Semaglutide is also effective for weight management in obese individuals, even those without diabetes

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