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On one hand, iron accumulation can upregulate the expression of Nav1.1 and Nav1.6 in the cortex and hippocampus, thereby modulating neuronal excitability (52, 53)
In addition to its effectiveness for weight loss, semaglutide may improve metabolic health, including better blood sugar control and lower cardiovascular risk factorsespecially important for our patients with overweight or obesity who also have type 2 diabetes
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After four weeks, the dose can be raised to 1 mg twice a day if symptoms are still uncontrollable
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