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Combined use of NNMT gene knockout and the product confirms causality:NNMT inhibition enhanced NAD+ synthesis improved energy metabolism This provides a complete experimental evidence chain for NNMT's regulatory role

AOD-9604 enhances one component of energy balance (fat oxidation from adipose stores) without creating the negative energy balance that results from appetite suppression or the metabolic rate increases seen with thermogenic compounds

While these studies suggest potential benefits, they do not provide the level of evidence needed to confirm safety and efficacy in humans