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( Lancet 2023, NCT04982575 [12] ) randomised 92 adults with type 2 diabetes on metformin, with or without an SGLT2 inhibitor, 1:1:1 to CagriSema (n=31), semaglutide (n=31), or cagrilintide (n=30), all escalated to 2.4 mg, across 17 US sites over 32 weeks
Cleveland Clinic, in its explanation of how gut and appetite hormones such as GLP-1 regulate fullness, describes the same hormone-driven hunger signaling that cagrilintide targets through the parallel amylin pathway
Its a research compound : not approved for therapeutic use by the TGA or any other regulator, and supplied strictly for laboratory and research purposes
It stimulates the production of extracellular matrix components such as collagen, elastin, and glycosaminoglycans
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