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PMID 37952131

The result is a measurable, consistent reduction in body weight over weeks and months not from willpower alone, but from genuine hormonal intervention

Enrolling Overweight Obstructive Sleep Apnoea Drug: NNC0487-0111 Drug: Placebo (matched to NNC0487-0111) Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease (PREVAIL) This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with Atherosclerotic Cardiovascular Disease (ASCVD)

In rabbits and cynomolgus monkeys administered semaglutide during organogenesis, early pregnancy losses and structural abnormalities were observed at below the MRHD (rabbit) and 5-fold the MRHD (monkey)