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The FDA does not regulate dietary supplements with the same rigor as pharmaceuticals, and most OTC GLP-1 products lack peer-reviewed clinical trials demonstrating meaningful weight loss or glycemic control benefits in humans
Most often, these side effects typically occur during the initial weeks of treatment and may improve over time as the body adjusts to the medication
Genomics 7, 291301
As a result, these types of medications formally known as glucagon-like peptide-1 receptor agonists, or GLP-1s could become more broadly available in the United States, where obesity affects around four-in-ten adults ages 20 and older
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