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Medicine has learned hard lessons from past cure-alls that went awry
Severe B12 deficiency is a health issue, not just feeling tired
Low-fat areas such as the inner thigh, the lower abdomen in leaner individuals, and sites near bony prominences should be avoided where possible as they offer less tissue cushioning and produce more pronounced discomfort
NaCl helps the osmotic component, but a buffered version of NAD+ addresses the actual cause. Tesamorelin is the one people get backwards: its FDA label specifies sterile water, but that is regulatory convenience, not the better diluent
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