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GIP-1 and GIP Semaglutide activates the GLP-1 receptor, prompting an increase in glucose-dependent insulin secretion
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DPP-4 can also have signaling functions via interactions with the extracellular matrix (90), and it was therefore speculated that the DPP-4 inhibitor might have improved insulin sensitivity by interfering with this process in some way rather than by blocking the enzymatic activity per se (79, 89)
Its not due to the drug
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