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The published trial reports treatment differences in kilograms rather than absolute percent loss per arm: Tirzepatide 5 mg: 1.9 kg more weight reduction than semaglutide 1.0 mg Tirzepatide 10 mg: 3.6 kg more weight reduction than semaglutide 1.0 mg Tirzepatide 15 mg: 5.5 kg more weight reduction than semaglutide 1.0 mg For blood sugar control, HbA1c fell by 2.30 percentage points on tirzepatide 15 mg and 1.86 percentage points on semaglutide 1.0 mg over the same period
Surgical intervention may be necessary if vegetations are causing obstruction, or if there is significant malfunction of a prosthetic valve
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