glutathione conjugation paracetamol Sex differences in metabolism and acetaminophen toxicity Glutathione-Mediated Conjugation of Anticancer Drugs:

J Biol Chem 279 : 2906029065 Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA, Hansen M, Schaefer E, Naoki K, Lader A, Richards W, Sugarbaker D, Husain AN, Christensen JG, Salgia R (2005) Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer

Different vial sizes require different water volumes to achieve target concentrations

The glycine part forms three hydrogen bonds with R289 and N345, with an average binding energy of 5.6 kcal/mol

Note: this high dosage bypasses the need for intrinsic factor to aid absorption