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78,215,216 With time the dead tissue is replaced with fibrotic scar surrounded by glia limitans barrier that fences the healthy tissue and assists post-stroke regeneration
Subsequently, this effect is reversed by the decreasing Nrf2 levels in the nucleus (nNrf2), leading to a decreased Keap1 level that is accompanied by a recovery of unbound Nrf2 because of a decreased sequestration in complexes with Keap1 (Fig 3C
Preclinical models are often employed to assess specific risks, including the potential to induce endocarditis in susceptible hosts (160)
The authors concluded that TB4 is a multifunctional regenerative peptide important in dermal repair, acting through promotion of cell migration, stem cell mobilisation and differentiation, and inhibition of inflammation and apoptosis
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