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They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology
Carnitine: this nutrient acts as a shuttle that moves long-chain fatty acids into a cellular organ called mitochondria
Whether this observation is solely the consequence of translocation of Parasutterella bacteria from the intestine to the EWAT or driven by more indirect mechanisms such as bacterially-produced metabolites 85 is yet to be determined
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