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12,13 Furthermore, disrupting TME-derived epigenetic cues, including CAF-derived exosomes and lactate-induced histone lactylation, may help dismantle pro-resistance niches and restore antitumor immunity

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Phase I trial of the PKC activator/downregulator bryostatin 1 (NSC 339555) and high-dose Ara-C (HIDAC) in patients with refractory acute leukemia

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