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In addition to its extensively studied actions in peripheral tissues, studies have evaluated the distribution of GLP-1R in the central nervous system (CNS) of rodents, non-human primates, and humans, showing that it is widely diffused to multiple CNS neurons including neurons of the arcuate nucleus (ARC), which are crucial for the control of energy balance (Fig
Support heart health, healthy energy level for proper heart function
In this regard, GLP-1 treatment leads to decreased expression of macrophagespecific markers for M1 (inducible NOS (iNOS), IL6 and TNF) and enhances expression level of M2-marker genes, including arginine1, macrophage galectin-1 (MGL-1), IL10, as well as mannose receptor-1 (MRC-1)
