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One important finding from clinical trials is that gastrointestinal side effects like nausea, vomiting, diarrhea are highly related to the medication dose and the rate the dose is increased

We would note that use of unregulated superpotent peptide tanning agents that hyperstimulate pigment synthesis have been reported to result in atypical nevi 45 and melanoma 46 , further supporting the potential adverse effects of hyperpigmentation

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An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis