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Association of menopausal hormone therapy with breast cancer incidence and mortality during long-term follow-up of the women's Health initiative randomized clinical trials

Insufficient or fragmented sleep can worsen insulin sensitivity, while large late meals may impair nighttime glucose handling and disrupt peripheral clocks in the liver, pancreas and gut

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Although this does not usually translate into major clinical effects for most vitamins and minerals, it may matter for compounds with short windows for absorption or narrow therapeutic indices