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Apart from this, other pathological processes take place in the CNS during MS, such as dysregulation of the blood-brain barrier (BBB) and of the coagulation system, defects in remyelination, gut microbiome alterations, changes in cellular metabolism and in microbial metabolites, dysfunction of the adenosinergic signaling pathway, increased apoptosis and defective autophagy (37)
Based on the precedent set by tirzepatide whose Phase 3 data preceded its diabetes approval by approximately one year analysts and regulatory observers expect a retatrutide NDA filing in late 2026 or early 2027, followed by a standard 10-to-12-month FDA review
Tennis champion Serena Williams has publicly discussed her use of GLP-1 medications and has partnered with a health company that connects consumers with telehealth weight-loss services
Long-term use may induce side effects such as cardiac arrhythmias or bone loss
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