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This deficiency frequently correlates with worse disease outcomes
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This risk is based on reports of antidepressants increasing the risk of suicidal thoughts or behavior in people ages 24 years and younger
In CY-5 experiments, substituting Lys 27 with Ile 27 , or Lys 27 , Asn 28 with Ile 27 , Ala 28 decreased the EC 50 of both GLP-1R and GIPR, but decreased hypoglycemic efficacies in mice
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