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Dietary interventions further expand this paradigm aged garlic oligosaccharides reshape gut ecology toward Akkermansia -dominant communities with concomitant TMAO reduction in hyperlipidemic ApoE -/- models, whereas hickory polyphenols attenuate atherosclerosis through hepatic FMO3 transcriptional downregulation in high-choline-fed C57BL/6J mice (167, 168)
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