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The bifurcated nature of current litigation (with gastrointestinal claims proceeding federally and vision loss claims advancing through state courts) creates pressure on manufacturers from multiple directions simultaneously, increasing the likelihood that Novo Nordisk and Eli Lilly will eventually pursue comprehensive settlement frameworks addressing both injury types

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Researchers studying gastrointestinal effects have used both acute (single-dose) and chronic (7-14 day) protocols, with efficacy observed in both paradigms