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Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis
We therefore distinguish evidence domains explicitly, with relatively robust support for short-term metabolic benefit but substantially greater uncertainty for reproductive translation and periconception safety
Human research remains limited, and potential risks such as immunogenicity may exist when sourced from unregulated materials
Both drugs are still under investigation
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