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For research protocols requiring isolated study of GH/IGF-1 axis effects, the CJC-1295/Ipamorelin combination provides cleaner data by eliminating cortisol and prolactin as variables

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Finally, another 48-week phase 2 study in subjects with hepatic steatosis but not T2D results in a mean weight loss of 25.9% compared to 0.1% for placebo (107)

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Burns says

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Some researchers find that their response to tirzepatide diminishes after months of use, even at the maximum 15 mg dose

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