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"Weight loss was associated with greater high-sensitivity CRP reduction in both treatment groups," said study presenter Jorge Plutzky, MD, director of Preventive Cardiology at Brigham and Women's Hospital, Boston, Massachusetts, but "with increased high-sensitivity CRP reductions in those receiving semaglutide." The drug also "significantly reduced high-sensitivity CRP early," he said, "prior to major weight loss and in those who did not lose significant amounts of weight." The reductions reached approximately 12% at 4 weeks and around 20% at 8 weeks, when the weight loss "was still quite modest," at 2% and 3% of body weight, respectively

Centrally, IRS1 dysfunction is associated with cognitive decline in AD [141]

Personalization: Genetic Testing Reveals Your Peptide Pathway Individual responses to semaglutide vary based on genetic predisposition to GLP-1 sensitivity