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IV Side Effects: Thyroid Dysfunction: It may cause hypothyroidism or hyperthyroidism because of changed hormone production
doi: 10.1016/j.clinme.2024.100030 [PubMed] 39407841 Scafetta T, Kovacs O, Milani GP, Bronz G, Lava SAG, Betti C, Vanoni F, Bianchetti MG, Far PB, Camozzi P
If a compound or molecule has low pK (less than 2.5), it has low affinity for binding protons
The effects of FGF23 are exerted primarily within the kidney where its actions result in increased phosphate excretion (decreased phosphate reabsorption) and suppression of calcitriol synthesis via inhibition of the expression of the CYP27B1 gene that encodes the PTH-inducible 1--hydroxylase enzyme
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