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All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)
Titration governs tolerability fast 2-week ramp to 15 mg gave 24.5% AE-discontinuation (Frias 2018)
These findings suggest oral administration can be effective, at least in rodent models
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