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PIONEER 4 adverse events vs liraglutide 1.8 mg 5 Comparator AE rates are not an adequate basis for comparison of safety between products Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice Data are n (%)

mGIPR-Ab treatment reduced total plasma cholesterol in Gipr fl/fl control mice but not in Gipr Syn/ mice

They also tracked how adverse event mentions fluctuated during key events, including the FDA approval of Wegovy for pediatric use in December 2022, Oprah Winfrey's public endorsement in December 2023, and the expansion of Medicare coverage for weight loss medications in March 2024