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During OA there is a loss of cartilage, the subchondral bone becomes thicker, the subchondral trabecular bone mass decreases and new osteophytes are formed [3]
[12] [13] The systemic availability of orally administered glutathione is poor
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Comprehensive GSH Antioxidant Function Review (PubMed, 2023) GSH as the Central Non-Enzymatic Antioxidant in Mammalian Cells A comprehensive review of reduced glutathione (GSH) published on PubMed confirmed that GSH is an essential non-enzymatic antioxidant in mammalian cells that acts directly to protect cells against free radicals and pro-oxidants, and as a cofactor for antioxidant and detoxification enzymes including glutathione peroxidases, glutathione S-transferases, and glyoxalases
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