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NRF2 regulates the 20S proteasome subunits PSMA1, PSMA7, PSMB3, PSMB5, and PSMB6 [8890], as well as the proteasome activator PA28 [73]

It is found in nearly every cell in the body, with higher concentrations in tissues such as the: Liver Lungs Brain Skin Eyes Gastrointestinal tract Glutathione plays a role in cellular processes related to antioxidant activity and maintaining internal balance

However, overexpression of GCLC almost completely rescued the inhibitory effects of CENPT silencing on GSH levels in mouse serum and tumor tissues (Fig

Therefore, studies on cellular fatty acid metabolism, membrane fatty acid composition, and ferroptosis, while limiting lipotoxicity, are gaining increasing attention from researchers