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Across the country poison control centers saw a nearly 1,500 percent increase in calls in 2023 related to accidentally overdosing on injected weight-loss drugs

There may still be limited use under 503A compounding rules, where a medication is prepared for an individual patient based on a specific clinical indication, but that pathway is much more restricted and not designed for widespread use. Jen Manne-Goehler, MD, ScD,assistant professor of medicine at Harvard Medical School, agreed

The fact that GLP-1R agonists have beneficial effects on both energy and glucose metabolism places this class of pharmacotherapies at a superior level compared to other drugs used to treat T2DM that cause weight gain

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