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FDA-approved GLP-1 medications were studied using defined titration schedules and therapeutic dose ranges
NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 30 kg/m with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically 27.5 kg/m) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity
Over the last decade and a half, several (injectable and most recent an oral) GLP-1 receptor agonist formulations have been introduced for the management of hyperglycemia in people with T2D [24]
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