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Its copper-mediated influence on lysyl oxidase activity, an enzyme critical to collagen cross-linking, is one proposed mechanism underlying these observations

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doi: 10.1056/NEJMoa2306963 29 SkrobuchaAPindlowskiPKrajewskaNGrabowskiMJonikS

PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage