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It is a dual GIP/GLP-1 receptor agonist the first medication in its class to activate both the GLP-1 receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor simultaneously
It isn't clear, however, whether the weight regain constitutes both fat and muscle, or mainly fat
All mice were uninephrectomized at 67 weeks old to promote hyperfiltration (Ninichuk et al., 2007
Instead, used hormones and their metabolites may remain in circulation longer than intended
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