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A 2019 randomized controlled trial from Cambridge and a German research team tested the wine before beer and beer after wine debate directly
10.3389/fnagi.2017.00068 Front
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91 In addition, lactylation at K91 of TFEB inhibits its interaction with the E3 ubiquitin ligase WWP2, leading to reduced ubiquitination and proteasomal degradation of TFEB, thereby resulting in enhanced TFEB activity
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