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This reflects a broader access problem that disproportionately affects lupus patients because their indication for these medications (managing corticosteroid-induced weight gain and reducing cardiovascular risk in an autoimmune condition) does not fit neatly into approved indication categories

When GLP-1 binds to these receptors, it directly influences their function: Macrophages: GLP-1s can shift macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, reducing inflammation in tissues like fat

This sudden release can impact your skin and trigger breakouts

In comparison, people taking a placebo tablet with no active medication lost around 3% of their starting body weight over the same period