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In addition to regulating metabolism, strong cardiovascular and renal outcome trial data (including STEP, SELECT, and FLOW) suggest that they can lower the disease burden of serious cardiovascular events and protect kidney functioning

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Research published in the European Journal of Endocrinology confirmed that even at doses more than 200-fold higher than needed for GH release, Ipamorelin did not affect ACTH or cortisol levelsa selectivity similar to natural GHRH itself