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Structural and functional characteristics of oestrogen receptor beta splice variants: implications for the ageing brain

Although direct clinical evidence for anti-HCC activity in humans is lacking, its ability to attenuate insulin resistance, oxidative stress, and the inflammation-fibrosis cascade may indirectly reduce HCC risk by optimizing the hepatic oncogenic microenvironment

Such gastrointestinal effects are a major reason for treatment discontinuation and are intrinsically linked to the mechanisms responsible for the weight loss efficacy of GLP-1RAs