OSA obstructive sleep apnoea, AHI apnoea-hypopnea index, CPAP continuous positive airway pressure, SGLT2 sodium-glucose co-transporters 2, EMPA empagliflozin, DAPA dapagliflozin, ERTU ertugliflozin, LUSEO luseogliflozin, GLIME glimepiride, MET metformin, SDB sleep disordered breathing, ODI oxygen desaturation index, BW body weight, RR relative risk, LSpO 2 minimum oxygen saturation, ESS Epworth Somnolence Scale, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, MED medication, Ref
A subsequent study confirmed that miR-34a modulates DDP resistance by directly repressing MET (Zhang et al., 2016)
Research in centenarians found that 6 months of L-Carnitine treatment (2 g/day) significantly increased muscle mass while reducing total body fat, alongside improvements in walking capacity and physical function
The table below is built from the published trial protocols