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Thus, all three of the main UA transporters may contribute to the brain concentrations of UA through their action at the blood-brain barrier, although ABCG2 is thought to have the greatest effect, probably acting to remove UA from brain to blood 45
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Such changes could be subtle yet impactful, and maintaining glutathione levels becomes critical
Endothelin receptor antagonists (ERAs) have been studied in diabetes and CKD for over a decade, with early studies ending prematurely because of complications associated with fluid retention
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