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Description

10.1038/304368a0 8 BellG

Metformin targets mitochondrial glycerophosphate dehydrogenase to control rate of oxidative phosphorylation and growth of thyroid cancer in vitro and in vivo

This mechanism becomes maladaptive in diabetes, however as hyperglycemia rise the expression and activity of sodium-glucose cotransporter (SGLT2) in the proximal tubule of the kidney