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Optimal dosing frequency: The peptides short plasma half-life (~0.5-2 hours) suggests frequent administration might sustain tissue concentrations more effectively than single daily dosing, but no formal dose-frequency comparison trials exist
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3.3.5.2 Probiotics In mice model of humid heatinduced anxiety, oral administration of probiotic Lactobacillus murinus for 14 days significantly reduced anxiety-like behaviors by restoring gut microbiota composition, which further downregulated neuroinflammatory markers (Weng et al., 2024)
