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J Invest Dermatol 97:10811085 Schallreuter KU, Wood JM, Ziegler I, Lemke KR, Pittelkow MR, Lindsey NJ, Gtlich M (1994) Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo

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This blockage of the blood and lymph vessels causes the physical manifestations of inflammation, namely redness, pain, stiffness, lack of mobility, and swelling

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