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When immediate-release exenatide is added to treatment with metformin and / or pioglitazone, the dose of metformin and/or pioglitazone may be continued as an increased risk of hypoglycaemia is not anticipated compared to metformin or pioglitazone alone

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5.2 Mitochondrial dysfunction Mitochondrial dysfunction plays a pivotal role in the pathogenesis of HTN-related OS, acting as both a major source and a vulnerable target of ROS in the cardiovascular system

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