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IFN- serves as a key initiating signal for M1 polarization by binding to IFNGR receptors and activating the JAK/STAT1 pathway resulting in STAT1 phosphorylation and upregulation of effector molecules such as iNOS CD86 and ROS (94, 95)
Shike, Modern Nutrition in Health and Disease, Lippincott Williams & Wilkins, 2006, 2069 pages
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