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Chemical modifications such as lipidation (first applied therapeutically to insulin in the 1990s), PEGylation (established as a platform technology in the early 2000s), and reversible albumin binding have transformed peptides from short-lived signaling molecules into durable therapeutics suitable for weekly or even monthly administration ( In parallel, advances in formulation science and delivery technologies have expanded the feasible routes of peptide administration
DOI:10.1186/1743-7075-9-35 [ Links ] 14
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Sci Rep 7:117
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