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Methods Experimental protocols Sixty C57BL/6J male mice (1820 g, 810 weeks, Changsheng Biotechnology Company, Liaoning, China) were housed and fed at the First Hospital of China Medical University, the Institute of Respiratory Disease, under quiet and controlled specific pathogen-free conditions
19 There are multiple problems with the trials assessing the use of rifaximin, 20 such as confounding effects of transjugular intrahepatic portosystemic shunt (TIPS) and surgical portosystemic shunts, 17 randomization imbalance, 21,22 lack of benefit in high risk populations (such as in prevention of HE in those undergoing TIPS), 23 and absence of objective HE scales in outcome assessment in some of the studies
Both GIPR and GLP-1R are expressed in overlapping brain regions including the ARC, PVN, and AP
